Endocrine Abstracts

Background: Tyrosine kinase inhibitors (TKI) are a chemotherapeutic group which include drugs known to cause thyroid dysfunction such as axitinib, imatinib, pazopanib, sorafenib, and sunitinib. However, reports of TKI-Ibrutinib causing thyroid dysfunction are scarce. Although several hypotheses have been proposed to explain TKI-associated thyroid dysfunction there is no clear guidance on how to manage this situation.Case: 86-year-old lady was referred to...

A 24 year old man was admitted by the Surgeons with left sided abdominal pain. He was febrile and tachycardic and found to have raised inflammatory markers. Abdominal CT scan revealed a 6 cm left adrenal haemorrhage with no evidence of an underlying lesion. Initial endocrine investigations were unremarkable for Cushings, Conn’s and adrenal insufficiency. Norepinephrine levels were high but settled subsequently. He had a coagulopathy and evidence of reactivation of EB viru...

Background: Graves’ Disease usually responds well to medical treatment with thionamides. However, in some cases, it fails to respond to this treatment, even at maximum doses. A few reported cases have shown that colestyramine helps to restore normal thyroid function when added to the ongoing anti-thyroidal medications in refractory thyrotoxicosis. We reported a case of relapsing refractory Graves’ disease, in which colestyramine has helped to restore normal thyroid f...

Background: Adrenal insufficiency (AI) is can be often under recognised condition in the clinical practise which can potentially result in adrenal crisis or even death if not treated properly. Identification of patients who are at risk of developing AI is important in order to take appropriate steps in minimising unwanted incidents. Objectives: Study aims to assess whether we identify patients who are at risk of AI and take recommended precautions.<p...